Editing Mewtwo (Anime) (section)

====''Pokémon Journeys: The Series''====
Since its departure from Mount Quena, Mewtwo began protecting several Pokémon that had been abused by humans. They eventually settled on the isolated Cero Island to live in peace.

In ''Getting More Than You Battled For!'', Ash and Goh traveled to Cero Island after Professor Cerise detected an energy signature similar to that of Mew coming from that location. After wandering around the island's wilderness for some time, Ash and Goh fell over a waterfall but were seemingly saved by Mewtwo, who rendered them unconscious and teleported them to a giant tree somewhere on the island. They encountered the Pokémon in Mewtwo's protection shortly before Mewtwo itself appeared and confronted them. Ash, recalling their previous encounter, recognized it, while Mewtwo did not indicate whether it remembered Ash or not. Mewtwo demanded to know why they had come to the sanctuary, leading Goh to reveal his search for Mew. In response, Mewtwo questioned how capturing all of the Pokémon in the world would lead Goh to Mew. Goh explained his belief that capturing Pokémon helps to understand them, and that capturing all Pokémon would thus help him understand Mew since it has the genes of all Pokémon species. Recognizing that Mewtwo was a Pokémon itself, he challenged it with the intent of capturing it. Mewtwo warned them that it was created to be the strongest Pokémon in the world, which motivated Ash to challenge it as well, in order to push himself further down the road to becoming a Pokémon Master. Smiling at their dedication to their dreams, Mewtwo consented to a battle. Despite Ash and Goh's best efforts, Mewtwo easily defeated Pikachu, Cinderace, and Lucario.

After the battle, Mewtwo asked Ash and Goh if they would still pursue their dreams, even though there would be many challenges ahead. In response, they affirmed their dedication to their goals, saying they could rely on their friends. Encouraged by this, Mewtwo revealed its role in protecting the abused Pokémon. Deciding to leave Cero Island with the Pokémon under its protection, Mewtwo parted with Ash and Goh, bidding them farewell with the promise that their journeys had only just begun. It then teleported them back to the Cerise Laboratory, allowing them to retain their memories of the encounter.