Editing Mewtwo (Anime) (section)

==Personality==
Throughout the course of the first movie, Mewtwo viewed all humans as its enemy, as Team Rocket's boss Giovanni would usually rely on it for his evil deeds, and the scientists strongly implied they were more pleased with the project being a success than its actual worth as a living being. However, ever since Ash was petrified by the attacks of both Mewtwo and Mew, Mewtwo had a change of heart and did everything to make sure that no one remembered what happened.

Its personality and motives beyond the initial misanthropy were largely different between the Japanese version and the English dub of the original movie. In the former, Mewtwo was insecure about its place in the world largely due to its status as a clone, and it preferred having a more direct confrontation between humanity and naturally-born Pokémon as revenge via its own cloned Pokémon, with the hurricane being more of a means to an end in bringing about this confrontation. In the latter, Mewtwo is significantly more confident in his status as stronger than any known Pokémon in existence, including its template, and it fully intended to destroy the entire world via hurricane as revenge against humanity. On a similar note, Mewtwo also had different reactions regarding developments to its plan, particularly the sudden appearance of its cloned Pokémon. In the Japanese version, he was taken by surprise by the explosion of its lab beneath them, while in the English version, it instead proudly declared "behold!", implying that it anticipated the lab explosion to occur as part of unveiling its clone army. Its characterization in the dub for the remake is much closer to that seen in the Japanese version.

It had calmed down considerably since the events in Kanto, and Mewtwo had grown into a guardian figure for its fellow clones. While it still questioned its place in the world, it felt responsible for its clones and was willing to sacrifice itself in order to keep them safe from harm. While still cautious regarding humans, Mewtwo was also willing to save them if the need called for it, such as when it used Psychic powers to save a busload of tourists; in the Japanese version, it conceded to Meowth-two's speculation that it did this due to having some care for the well-being of the humans (although it was mostly out of pragmatism due to wanting to avoid the risk of being discovered by the resulting news choppers). Its view on humanity was further changed as Ash helped Mewtwo to Purity Spring, when Mewtwo wondered why Ash would help it, Ash claimed that no one needs a reason to help someone. Mewtwo's outlook on life was further influenced by how the spring affected it. As the waters had the same restoring effect on it as they did on other Pokémon, it concluded that the world was its rightful place as well.

After the military operation on Mount Quena came to a head, Mewtwo had initially contemplated on erasing the memories of everyone involved. However, it took Meowth's speech into consideration, as erasing their memories would prevent the clones from learning about their past, and forgetting would not change the fact that things happen. Mewtwo decided to only erase the memories of Team Rocket—excluding Jessie, James, and Meowth—and departed.

By ''Pokémon Journeys: The Series'', Mewtwo had again taken up the role of a protector, this time to a group of Pokémon abused by humans. Even though it did not try to hide its strength, it had mellowed even further following the Mount Quena events, to the point where Ash and Goh's dedication to their dreams made it smile.